The Evidence

Because research without results
is just theory.

One family. Two children. Two adults. A specific start date. Documented outcomes at 8 months — updated at one year.

Living document — updated at one year
Why Now

The Story page tells you how I got here. The Research page tells you why the biology works. This page tells you what actually happened.

I am publishing this at 8 months because I think waiting for "enough" data is the thing that keeps this information from reaching the people who need it. This is enough. I will update it at one year.

Published: May 2026 — 8 months in. This page documents outcomes from October 1 onward. A one-year update will be added when we reach that mark. The story is ongoing.

The Setup
Start Date October 1
Protocol L-5-methylfolate (Triquetra Health 15mg) + methylcobalamin B12, with B2, P5P, and magnesium glycinate as cofactors. No folic acid. Synthetic dyes removed from diet.
Who Two children. Two adults. All MTHFR variants confirmed or clinically indicated.
Approach Started low. Increased gradually. Watched closely.
My Youngest — Age 9 at Start

ASD Level 2  ·  High Hyperactive ADHD  ·  Largely Nonverbal

The moment that said everything

"Turn it down."
"Who — me or my brother?"

That exchange happened on an ordinary day. No appointment. No milestone marker. Just a normal sibling moment where someone was too loud and someone else needed to know which someone that meant.

Eight months ago that response was not possible. Not because he couldn't hear the words. Because the cognitive architecture underneath it — understanding that a question can have two answers, that the person asking doesn't know which one they mean, that he needed to ask before he could act — that architecture wasn't there yet.

Now it just… is. That is what cognition coming online looks like. Not a test. Not a therapy session. A Tuesday afternoon where a 9 year old responded to his mom exactly the way any kid would.

That's the whole thing right there.

Before October 1

He sang before he spoke. That detail matters — it means the capacity was always there. Music found a channel that language hadn't opened yet.

From ages 3 to 9, communication came in isolated fragments. Demands for concrete needs. Milk. A toy. A yes or no. But not conversation. Not concepts. Not the kind of language that builds a relationship between two people.

He was terrified of animals. Terrified of most new things. The world was loud and hard and too much.

Looking back, there were small windows — brief periods where something shifted, where gains appeared and then plateaued. I didn't understand them then. I do now. They were the periods I accidentally introduced the right form of folate without knowing it. The gains were real. The plateau happened when I stopped.

What happened — week by week

Weeks 1–2: Sleep improved. He seemed calmer. Hard to tell if it was real or hopeful thinking.

Weeks 3–4: His former teacher saw him without knowing we had changed anything. She sent me a message I did not ask for:

What I really see is that he's the same wonderful kid I've always known. The difference I saw was truly that he didn't seem trapped behind his eyes — all of him was showing up. The ease and joy that I could see in his whole little body was just delightful to witness. His giggles warmed my heart, and his reading and listening skills blew my mind.

— A former teacher, 30 days after supplementation began. Unsolicited.

Months 2–4: Language started accelerating. Not just words — concepts. He began understanding and participating in conversations that had context, nuance, back and forth. The kind of conversation we had been told to manage our expectations about. He started reading. Close to grade level.

Months 4–8: He decided our guinea pig needed a girlfriend so they could have babies. He has a name picked out. He has the whole plan mapped. He has opinions and he shares them loudly and without filter. He walks up to strangers and says exactly what he observes with zero self-censorship. He lies. He's sneaky. He blames things on his brother. He smiles when he gets caught.

These are not red flags. These are theory of mind. This is a brain doing things we were not sure it would do.

One afternoon his dad said it was too late to go swimming. He took our analog clock off the wall and moved the hands back. The logic was airtight — the clock said earlier, therefore it was earlier, therefore swimming was still possible. He just needed the adults to see what he saw.

That is not a child we worry about anymore. That is a child we try to keep up with.

On connection

For years, playdates meant chasing him. He loved the running. He loved the chase. The other kids, the connection, the play itself — that wasn't the draw. We spent years arranging what he ran away from, and I got into genuinely great shape doing it.

Now he sees kids and he moves toward them. He tries to join. Patient kids let him in. Others don't. He notices but he keeps trying.

He wants to belong. He didn't used to want that because he didn't understand there was something to want.

That's the whole shift right there. Not arrival. Wanting. And wanting, after years of running, is everything.

At 8 months

That last one used to be the fear. Now it's the joy.

My Older Son — Age 13 at Start

ASD  ·  High ADHD  ·  Anxiety-driven, internalized profile

Before

Functioning. Verbal. Capable. But running on a system that was working too hard to hold itself together. Anxiety present. Temper unpredictable. Hyperactivity that made sustained focus expensive.

What happened

Calmer. Measurably, noticeably calmer. The anxiety that used to run underneath everything — quieter. The temper that would spike — mellowed. The hyperactivity — reduced enough to matter.

He knows the difference. He can feel it. When he misses a dose he describes it the way someone describes missing their morning coffee — sluggish, irritable, off. He's 13 and he understands his own biology well enough to know what's supporting it.

He is not on this protocol because someone told him to be. He's on it because he experienced the before and the after and made the connection himself.

At 8 months

The Adults — Both of Us

Me

I started this research because of my children. I stayed because of what it explained about me.

Iron that would never hold. Dizziness when I stood up. Brain fog that came and went. Anxiety with no proportionate cause. A nervous system that felt permanently slightly too activated.

All of it has a name now. All of it has a mechanism. And addressing the mechanism addressed the symptoms.

At 8 months

My Partner — Diagnosed OCD and ADHD

He didn't start this journey with me. He watched the changes in our children and eventually tried it himself.

OCD that had defined his baseline for years — meaningfully mellowed. ADHD calmer. He notices when he misses his folate the same way everyone in this house does. Something is just off. Sluggish. Irritable. He knows exactly why. He didn't need a study to make the connection. He felt it himself.

At 8 months

Across This Household at 8 Months
0
Psychiatric medications in use across the family
4
People who have seen meaningful, documented improvement
1
Biological pathway underlying all of it
8 mo
Since October 1. Updated at one year.

Because now it is.

What This Is and Isn't

This is one family's documented experience. It is not a clinical trial. It is not a guarantee. Your biology is your own and your results will be your own.

What I can tell you is that the pathway is real. The research supports it. And when you address the actual biological root instead of managing the downstream symptoms, things change.

The research is in Chapter 4. The protocol is in Chapter 6. The doctor conversation is on the For Your Doctor page.

This page will be updated at the one year mark.

Because this story isn't finished. It's just well underway.

Ready to walk through the research?

The same questions I asked, in the same order. Start at Chapter 1 and see where it leads.

Begin The Research → Talk To Your Doctor →